Dad's Absence Affects Neurobiology of Offspring

Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) have discovered that an absent father during critical growth periods can lead to social and behavioral impairments in adults. This is the first study of its kind to correlate paternal deprivation and social attributes with physical changes in the brain.

"Although we used mice, the findings are extremely relevant to humans," says senior author Dr. Gabriella Gobbi, a researcher of the Mental Illness and Addiction Axis at the RI-MUHC and an associate professor at the Faculty of Medicine at McGill University. "We used California mice which, like in some human populations, are monogamous and raise their offspring together."

Researchers were able to control the environment in which the mice were raised, including the factors among the different groups.  As a result, mice studies may be clearer than human studies claims Francis Bambico, a former student of Dr. Gobbi at McGill and now a post-doc at the Centre for Addiction and Mental Health (CAMH) in Toronto.

Researchers compared the social behaviour and brain structure of mice in different groups; those raised with both parents and those raised by their mothers. Findings show that mice raised by single mothers experienced abnormal social interactions and were more aggressive than those raised with both parents present. In addition, these findings were more prevalent among female mice.  Furthermore, females also experienced an increased sensitivity to amphetamine.

"The behavioral deficits we observed are consistent with human studies of children raised without a father," says Dr. Gobbi, who is also a psychiatrist at the MUHC. "These children have been shown to have an increased risk for deviant behavior and in particular, girls have been shown to be at risk for substance abuse. This suggests that these mice are a good model for understanding how these effects arise in humans."

Further studies may uncover a clearer reasoning for such findings.  Is it merely the presence of a male role model?  Could it be that two parents, regardless of gender, have more influence than one?  Could male mice be more sensitive to amphetamine if raised by fathers alone?  Many questions remain for future studies to uncover, however this research demonstrates that the role of the father and/or the presence of both parents during critical stages of growth appear to be relatively important in children's mental health development. 

Dads: How Important Are They? New Research Highlights Value of Fathers in Both Neurobiology and Behavior of Offspring

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Infants Trained to Concentrate May Have Improved Abilities

New research suggests that infants can be trained to improve their concentration skills much earlier than once thought, which, unlike adults, can lead to improvements on unrelated tasks. Such abilities could lead to greater academic success, especially for those infants that may not be expected to thrive.

"Research suggests that differences in attentional control abilities emerge early in development and that children with better attentional control subsequently learn better in academic settings," said Sam Wass of the Centre for Brain and Cognitive Development at Birkbeck, University of London.

In other words, infants that can more readily concentrate on a specific object while ignoring other distractions are better equipped to learn. To test this theory, researchers observed 42 eleven-month-old infants on 5 occasions over 15 days. The cognitive abilities of each child were tested at the beginning and end of the 15 day period. Half of the babies watched TV, while the other half explored images on a computer screen. The latter half were tested to see how long they could watch a butterfly that flew only as long as they kept their eyes on it, meanwhile other distracting elements appeared on the screen.

Results showed that, “trained infants rapidly improved their ability to focus their attention for longer periods and to shift their attention from one point to another. They also showed improvements in their ability to spot patterns and small but significant changes in their spontaneous looking behavior while playing with toys”.

Consequently, the ability to stay focused on a task or to quickly shift attention can facilitate learning and social interactions, which can significantly impact abilities later in life.

Although the plasticity of the infant brain might allow training to occur at an earlier age, it remains a mystery whether infants might lose their novel skills just as quickly as they were learned.

Infants Trained to Concentrate Show Added Benefits

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Is Facebook Really Bad For Your Health?

Psychologist, Aric Sigman suggests that the use of social networking sites as opposed to face-to-face interaction could lead to major health problems. Dr. Sigman claimed in the British Journal, The Biologist, that spending too much time online could lead to social isolation, loneliness and a negative outlook. These types of psychological symptoms could eventually lead to more serious health concerns, such as heart disease, cancer and dementia.

Time that was previously spent interacting socially has increasingly been displaced by the virtual variety,” Sigman said in his article. “While the precise mechanisms underlying the association between social connection, morbidity and morality continue to be investigated, it is clear that this is a growing public health issue for all industrialized countries.

Internet psychology expert, Andrew Dillon, clearly believes that this is yet another new tool that is being used to create panic and predict the burden it may have on society; much like the criticism television has received over the years. Dillon attacks Sigman’s credibility and scientific methods, claiming that too much weight has been placed on evidence supporting his views, while purposely excluding information that might not support his claims. Of course, conclusions should always be drawn based on all evidence, for and against, however, if more evidence exists for a claim would one not be inclined to believe it?

I’m not sure where to stand in this debate, but I do know that I haven’t much faith in what Andrew Dillon has to offer after watching this video. He seems quick to criticize and incapable of supporting his own claims.

Sure, it seems plausible that in this day and age, people are spending more time online than in person and this could negatively impact our physical and mental health, but I would certainly need more convincing research to buy into the fact that it could lead to dementia or cancer.

Many studies exist that link internet use to mental health issues.

“After 1 to 2 years, increased use of the Internet was associated with decreased family communication and reduced size of local social circle. In addition, the participants experienced increased loneliness and depression. Increases in loneliness and decreases in social support were particularly pronounced for the youth.”

Conversely, there’s evidence suggesting that social networking online may have no effect and may even benefit individuals:

“The results show that the Internet was adopted sooner by individuals with high financial, human and social capital. Furthermore, the results suggest that Internet use is not associated with a reduction in respondents' networks or with the time they spent socializing with friends. Instead the findings suggest that the time users devote to the Internet is taken away from the time they spend on watching television.”

Despite the controversy, there is obviously a clear distinction between virtual and reality, but there is no conclusive evidence that suggests Facebook is neither harmful nor beneficial to one’s mental health at this point in time. I suppose, my humble opinion would be like anything else; all things in moderation.

An overview of Dr. Sigman’s findings can be read here.

Psychologist alleges that too much time online causes major health risks
Social Capital and the Internet: Evidence from Swiss Panel Data
The Relationship Of Internet Use To Depression And Social Isolation Among Adolescents

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Parental Ignorance and Infant TV Programming

Professor and paediatrician, Dimitri Christakis of the Seattle Children’s Research Institute and the University of Washington, has published a summary of research findings in Acta Paediatrica that support the claim that television viewing for infants under the age of two actually does more harm than good.

Professor Christakis maintains that infant TV viewing is associated with delayed language, with shortened attention spans and with delayed cognitive development. This may be, in part, due to the overstimulation of the brain from TV programs flashing lights, quick screen changes, auditory cuts etc. Christakis reviewed 78 studies from the past 25 years and could not find one that actually provides supporting data that television can help the developing brain.

Some Key Findings:

• 29% of parents in a 2007 American study allowed their infants to watch TV because they believed it would promote brain development, despite a lack of real scientific evidence.


• Educational programs developed for infants can actually delay language development according to many studies.


• Infants imitate what they see on TV, but learn better from live presentations.


• A 2004 study of 1,300 children found a modest association between infant TV viewing and attention problems by age 7 while ruling out many factors.


• School age children who watched a lot of TV as infants performed more poorly on reading and memory tests.


• More than 1 in 5 parents in one study allowed their infants to watch TV because they needed time for themselves.

Evidently, companies in the educational TV programming business dispute these findings. With the average age where children begin watching TV dropping from 4 in 1971 to 5 months of age today, the exploitation of this demographic group likely runs parallel to this trend as companies like Baby Einstein and Baby Genius develop their TV shows that aim to support the developing brain. It’s not difficult to see how parents can be so easily deceived. After all, who wouldn’t want their child to excel? These companies work hard and spend a lot of money on marketing tactics in order to persuade parents that their products are beneficial. But, when the evidence doesn’t support the claims, parents need to be made aware of the damage TV can have on their children. Undoubtedly, more money is available to market the benefits of these products than there is available to fund research grants that prove these products have the exact opposite affect that they endorse.

The American Academy of Paediatrics discourages TV viewing in the first two years of life, but only six per cent of parents are aware of this advice despite ongoing publicity.

Letting Infants Watch TV Can Do More Harm Than Good
Baby TV time slows development: Research

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Tis' the Season for Family Feuding

During the hustle and bustle of this busy time of year most of us are spending a significant amount of time with our family over the holidays. Now, the season is not complete without a customary family fight, but has anyone ever stopped to ask themselves why arguments can get so easily heated with our family members?

Researchers, Steven Platek and Shelly Kemp have recently raised this very question. The study is the first to compare brain activity associated with seeing relatives with that linked to seeing friends and strangers. It suggests our feelings about biological relatives are at least somewhat primal. Their research analyzed MRI brain scans while subjects viewed images of relatives, family, friends, themselves and morphed images. Results showed that our brain tends to rank people socially and our family takes first place. These findings may help to explain the phenomena that our relatives get under our skin more easily than others. Also, brain scans demonstrated that images of our relatives are processed in parts of the brain related to self-reference, which suggests that we may take things more personally due to a resemblance to family members. While we may tolerate a friend's loud laughter or snoring, for example, we may have less patience with a relative because we judge them similarly to how we judge ourselves.

Consequently, this is something to bear in mind the next time you might feel your blood pressure rising in response to your family. Although this research is informative, I’m still interested to identify the point at which a stranger becomes a friend or a friend becomes a relative in terms of brain activity?

Visiting family warps your brain, study says

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Fast Food Junkies At Risk of Alzheimer's Disease

The Swedish medical university Karolinska Institutet (KI) published a doctoral thesis that links Alzheimer’s disease with high levels of fast food intake. In the study, Susanne Akterin observed mice that were fed diets rich in fat, sugar and cholesterol. After only nine months, the rats had developed what looked like the preliminary stages Alzheimer’s disease. More specifically, the irregularities found in the brain had greatly resembled those of early Alzheimer’s.

Although the exact causes of Alzheimer’s disease remains unknown, there are many identified risk factors, such as “a variant of a certain gene that governs the production of apolipoprotein E, one of the functions of which is to transport cholesterol”. This study sought to demonstrate the link between this risk factor and diet in mice.

Basically, the brains of these rats were modified to mimic the effects of the apoE4 gene variant by ingesting a diet similar to fast food for nine months. The results showed a chemical change in the brain comparable to that found in Alzheimer’s patients.

The change in question was an increase in phosphate groups attached to tau, a substance that forms the neurofibrillary tangles observed in Alzheimer’s patients. These tangles prevent the cells from functioning normally, which eventually leads to their death. Ms Akterin and her team also noted indications that cholesterol in food reduced levels of another brain substance, Arc, a protein involved in memory storage.

In short, the results of this study suggest that a diet high in fat/cholesterol combined with genetics can potentially contribute to the development of Alzheimer’s disease. Although, there has been no direct causal link identified, the study has provided yet another reason to lay off the burgers and fries.

Fast Food A Potential Risk Factor For Alzheimer’s

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The Rolling Stones: A Form of Music Therapy

In recent news, a 60 year old grandfather of Stoke, England, awoke from a 10 week coma when he heard the sound of "I Can’t Get No (Satisfaction)" by the Rolling Stones pumping through his headphones.

Sam Carter slipped into a coma after developing severe anaemia. Doctors were not very hopeful about his recovery. In fact, his survival rate was a mere 30%. His wife was reluctant to use a 'music therapy' approach, but all else was failing.

After many weeks of silence, Sam said:

I can't remember much from being in a coma, but I do remember that when that song came on it took me right back to when I was a youngster. I could remember how excited I was to get it down at the record shop. I suddenly had a burst of energy and knew I had a lot more life left in me and that's when I woke up - to the sound of the first song I ever bought.

When I heard about this miracle, it reminded me of how music therapy is sometimes used in cases of acquired brain injury, autism, emotional traumas, geriatric care, hearing impairments, speech and language impairments, substance abuse, and many other areas of mental health. This form of therapy does not seem to get the attention and credit it might deserve. Music therapy uses music and musical elements to treat physical, emotional, cognitive and social problems. The music can facilitate contact, interaction, self-awareness, learning, self-expression, communication, and personal development.

Many questions come to mind regarding the efficiency of music therapy. How does it work and does it work in the same way for everyone? What type of music works best? What sort of brain injuries respond better to this form of therapy? When is it the best treatment option? Who should perform this type of therapy and is there a certified body governing its use? Are success rates linked to age, severity of damage etc?

Unfortunately, the answers to most of these questions are rarely black or white. In terms of an exact methodology; none seems to exist. There is no step by step approach. Instead, many differing methods are used to develop communication, language and intellectual development, assist in the grieving process, relieve stress, motivate rehabilitation, aid memory and imagination etc. Music therapy works by keeping the patient's attention, structuring time, providing an enjoyable method of repetition, helping memory, encouraging movement, and tapping into memories and emotions. Many studies attest to these findings, such as, a Finland study suggesting that listening to music shortly after a stroke can facilitate cognitive and emotional recovery.

But, how exactly does music affect the brain? Researchers at Georgetown University Medical Center demonstrated that

one brain system, based in the temporal lobes, helps humans memorize information in both language and music— for example, words and meanings in language and familiar melodies in music. The other system, based in the frontal lobes, helps us unconsciously learn and use the rules that underlie both language and music, such as the rules of syntax in sentences, and the rules of harmony in music.

Still, it is not easy to identify when this alternative treatment is most appropriate. It appears to be used most often when all else has failed, as was the case with Sam Carter, however since it doesn’t cause any harm it might be best not to leave this option as a last resort.

I have also discovered that the Canadian Association for Music Therapy (CAMT) is a national body that lists accredited University educated music therapists for anyone seeking this form of therapy.

Some interesting facts:

The information most adults consistently recall from childhood is songs and rhymes.

Emotional engagement is the key to effective learning. Music therapy engages the emotions; thus unlocking the brain and preparing it for learning.

People have at least seven distinct intelligences. One of these intelligence areas is the musical area. Often people with special needs learn best through music because that part of the brain is an older part of the brain and less likely to be damaged from birth defects, accidents, etc.

Research studies have shown that 80 - 90% of individuals with autism respond positively to music as a motivator.

Research has shown that music is a valued tool for stimulating the right side of the brain; and also is helpful in encouraging bilateral activity between the brain hemispheres.

The area of the brain that responds to music is located in a different area than the speech and language area.

The following video depicts how music therapy can help to develop new ways of communicating and teach new skills to children with severe disabilities:



Sources:

Riverbend Down Syndrome Parent Support Group
Music Therapy - Getting Cured Through Melody
Listening To Music Improves Stroke Patients' Recovery, Study Shows
Rolling Stones classic wakes grandfather from coma
Music And Language Are Processed By The Same Brain Systems
Canadian Association for Music Therapy

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Size Does Matter

Researchers of the Layton Aging & Alzheimer's Disease Center at Oregon Health and Science University (OHSU) in Portland have discovered that brain volume is linked to mental decline in people with Alzheimer's.

This linkage was discovered while performing autopsies on deceased elderly patients. The entire brain was found to be larger in patients who had not experienced any cognitive impairment. In particular, the hippocampus, a part of the forebrain in the medial temporal lobe that plays a major role in long term memory, has been discovered to be larger in size for those patients with no cognitive impairments. Most surprising, those in both categories had plaques and tangles in the brain as found in typical Alzheimer patients.

The study consisted of 12 patients who did not have Alzheimer's symptoms before death and 24 who had experienced symptoms of the disease. As per Dr. Deniz Erten-Lyons, the brains of those without symptoms of Alzheimer’s were found to be on average 10% larger.

Dr Jeffrey Kaye, director of the Layton Aging and Alzheimer's Disease Center and a professor of neurology in the OHSU School of Medicine stated: "We are hopeful that this research will help us further understand the structural and genetic ties to Alzheimer's disease and perhaps offer clues that may help us develop new drugs or therapies."

This study could help lead the way to developing better tools for earlier detection rather than relying heavily on evaluations of thought process through mental tests. All studies seem completely worthwhile when up against a degenerative and terminal disease that has no cure and affects millions worldwide every year.

Source

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Extreme Stress in the First Trimester Associated with Schizophrenia

There already exists much evidence of low birth weights and pre-maturity among newborns of mothers that suffer stressful life events during pregnancy. "Chemicals released by the mother’s brain in response to stress may have an effect on the fetus’ developing brain. These effects may be strongest in early pregnancy, when protective barriers between the mother and fetus are not fully constructed."

Schizophrenia is believed to commence during early brain development; however environmental factors during a pregnancy may influence the risk of developing schizophrenia.

A study conducted by Ali S. Khashan of the University of Manchester suggests a likelihood of developing schizophrenia when a child’s mother experiences a stressful event during the first trimester of pregnancy.

The subjects in this study consisted of 1.38 million Danish births occurring between 1973 and 1995. A national registry was used to verify relatives of the mothers that either passed away or received a diagnosis of cancer, heart attack or stroke during the course of their pregnancy. Khashan found that during their pregnancies, the mothers of 21,987 children were exposed to the death of a relative, mothers of 14, 206 children were exposed to a relative receiving a diagnosis of cancer, heart attack or stroke, and most striking, 7,331 children observed had eventually developed schizophrenia.

Results illustrated a 67% greater risk of developing schizophrenia or other disorders when exposed to the death of a relative during the first trimester. Six months prior to pregnancy or any other time during the pregnancy held no significance in the development of schizophrenia. As well, the significance appeared only in those without a family history of mental illness.

Although, the study only assesses risk and is not suggesting any concrete findings, it would have been more informative to have knowledge the schizophrenics’ age at the end of the study in order to rule out any possible association with societal changes or social upheavals. Also, research on a more global perspective would certainly have supported the validity of the study. Overall however, this does provide a decent starting point for future research.

Article

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Biological Basis of Addiction

I stumbled upon an article today regarding addiction, an area of study that has been of interest for many years. The research conducted at Indiana University examined the possibility that structural changes in the amygdala may be responsible for the co-morbidity of addiction and mental illness. Those who are familiar with addiction or have worked with addicts know just how often this combination occurs.

The study compared the behaviour of adult rats that had both undergone surgery on their amygdala during infancy. One group had their amydalas damaged while the control group’s amygdalas were left intact. The control group experienced a type of mock surgery.

Interestingly, those that grew up with damaged amygdalas showed more response to novel stimuli, less fear to elevated mazes, continued social activity in the presence of a predator’s scent, were more sensitive to cocaine after only one exposure, and demonstrated consistency of behaviour changes with repeated cocaine injections. All conditions are stated to have remained constant; therefore results are directly related to the amygdala.

This proposes that the structure of the brain can affect vulnerability to drug addiction. Also, with regards to dual diagnosis it suggests that this vulnerability to addiction more effectively explains the high rates of addicts suffering from other mental illnesses as opposed to drug use causing mental illness.

This seems to suggest that a better response to treat mental illness is to reduce pharmacological treatment, a position that I have held from day one of my studies in psychology.

Full Article

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